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1

Deregulation of Hippo–TAZ pathway during renal injury confers a fibrotic maladaptive phenotype

Anorga, Sandybell, Overstreet, Jessica M., Falke, Lucas L., Tang, Jiaqi, Goldschmeding, Roel G., Higgins, Paul J., Samarakoon, Rohan

Journal:

The FASEB Journal

Year:

2018

Language:

english

File:

PDF, 2.94 MB

english, 2018

2

Loss of tumour suppressor PTEN expression in renal injury initiates SMAD3- and p53-dependent fibrotic responses

Samarakoon, Rohan, Helo, Sevann, Dobberfuhl, Amy D, Khakoo, Nidah S, Falke, Lucas, Overstreet, Jessica M, Goldschmeding, Roel, Higgins, Paul J

Journal:

The Journal of Pathology

Year:

2015

Language:

english

File:

PDF, 2.64 MB

english, 2015

3

Anatomy of Teaching Anatomy: Do Prosected Cross Sections Improve Students Understanding of Spatial and Radiological Anatomy?

Samarakoon, L. B., Vithoosan, S., Kokulan, S., Dissanayake, M. M., Anthony, D. J., Dissanayake, Vajira, Jayasekara, Rohan

Journal:

Anatomy Research International

Year:

2016

Language:

english

File:

PDF, 1.08 MB

english, 2016

4

Ureteral Obstruction-Induced Renal Fibrosis: An In Vivo Platform for Mechanistic Discovery and Therapeutic Intervention

Dobberfuhl, Amy D., Samarakoon, Rohan

Journal:

Cell & Developmental Biology

Year:

2012

Language:

english

File:

PDF, 790 KB

english, 2012

5

MP10-02 PLASMINOGEN ACTIVATOR INHIBITOR-1 (PAI-1) EXPRESSION PROMOTES FIBROTIC RENAL TUBULAR DYSFUNCTION

Lian, Fei, Tang, Jiaqi, Arnouk, Alex, Samarakoon, Rohan, Higgins, Paul

Journal:

The Journal of Urology

Year:

2018

Language:

english

File:

PDF, 144 KB

english, 2018

6

Deregulation of Negative Controls on TGF-β1 Signaling in Tumor Progression

Tang, Jiaqi, Gifford, Cody, Samarakoon, Rohan, Higgins, Paul

Journal:

Year:

2018

Language:

english

File:

PDF, 979 KB

english, 2018

7

TGF-β1-induced PAI-1 expression is E box/USF-dependent and requires EGFR signaling

Stacie M. Kutz, Craig E. Higgins, Rohan Samarakoon, Stephen P. Higgins, Rosalie R. Allen, Li Qi, Paul J. Higgins

Journal:

Experimental Cell Research

Year:

2006

Language:

english

File:

PDF, 1.19 MB

english, 2006

8

1152 RENAL PROTEIN PHOSPHATASE 1A (PPM1A) REDUCTION ACCOMPANIES PATHOLOGIC HYPERACTIVATION OF TRANSFORMING GROWTH FACTOR-BETA (TGF-β1) / SMAD SIGNALING IN OBSTRUCTIVE UROPATHY

Dobberfuhl, Amy D., Overstreet, Jessica M., Mian, Badar M., Samarakoon, Rohan, Higgins, Paul J.

Journal:

The Journal of Urology

Year:

2013

Language:

english

File:

PDF, 58 KB

english, 2013

9

1-Induced Expression of the Poor Prognosis SERPINE1/PAI-1 Gene Requires EGFR Signaling: A New Target for Anti-EGFR Therapy

Samarakoon, Rohan, Higgins, Craig E., Higgins, Stephen P., Higgins, Paul J.

Journal:

Journal of Oncology

Year:

2009

Language:

english

File:

PDF, 1.23 MB

english, 2009

10

The TGF-β1/p53/PAI-1 Signaling Axis in Vascular Senescence: Role of Caveolin-1

Samarakoon, Rohan, Higgins, Stephen P., Higgins, Craig E., Higgins, Paul J.

Journal:

Year:

2019

Language:

english

File:

PDF, 2.08 MB

english, 2019

11

TGF-β1 → SMAD/p53/USF2 → PAI-1 transcriptional axis in ureteral obstruction-induced renal fibrosis

Rohan Samarakoon, Jessica M. Overstreet, Stephen P. Higgins, Paul J. Higgins

Journal:

Cell and Tissue Research

Year:

2012

Language:

english

File:

PDF, 407 KB

english, 2012

12

[Advances in Pharmacology] Vascular Pharmacology: Cytoskeleton and Extracellular Matrix Volume 81 || The Cytoskeletal Network Regulates Expression of the Profibrotic Genes PAI-1 and CTGF in Vascular Smooth Muscle Cells

Samarakoon, Rohan

Year:

2018

Language:

english

File:

PDF, 480 KB

english, 2018

13

Plasminogen activator inhibitor type-1 gene expression and induced migration in TGF-β1-stimulated smooth muscle cells is pp60c-src/MEK-dependent

Rohan Samarakoon, Craig E. Higgins, Stephen P. Higgins, Stacie M. Kutz, Paul J. Higgins

Journal:

Journal of Cellular Physiology

Year:

2005

Language:

english

File:

PDF, 536 KB

english, 2005

14

pp60c-src mediates ERK activation/nuclear localization and PAI-1 gene expression in response to cellular deformation

Rohan Samarakoon, Paul J. Higgins

Journal:

Journal of Cellular Physiology

Year:

2003

Language:

english

File:

PDF, 376 KB

english, 2003

15

PAI-1 Mediates the TGF-β1+EGF-Induced “Scatter” Response in Transformed Human Keratinocytes

Freytag, Jennifer, Wilkins-Port, Cynthia E, Higgins, Craig E, Higgins, Stephen P, Samarakoon, Rohan, Higgins, Paul J

Journal:

The Journal of Investigative Dermatology

Year:

2010

Language:

english

File:

PDF, 5.03 MB

english, 2010

16

MP29-04 THE LOSS OF PTEN CONSEQUENT TO URETERAL OBSTRUCTION CONTRIBUTES TO RENAL FIBROSIS

Helo, Sevann, Samarakoon, Rohan, Dobberfuhl, Amy, Higgins, Paul

Journal:

The Journal of Urology

Year:

2015

Language:

english

File:

PDF, 39 KB

english, 2015

17

Redox control of p53 in the transcriptional regulation of TGF-β1 target genes through SMAD cooperativity

Overstreet, Jessica M., Samarakoon, Rohan, Meldrum, Kirstan K., Higgins, Paul J.

Journal:

Cellular Signalling

Year:

2014

Language:

english

File:

PDF, 1.04 MB

english, 2014

18

Differential requirement for MEK/ERK and SMAD signaling in PAI-1 and CTGF expression in response to microtubule disruption

Rohan Samarakoon, Craig E. Higgins, Stephen P. Higgins, Paul J. Higgins

Journal:

Cellular Signalling

Year:

2009

Language:

english

File:

PDF, 1.83 MB

english, 2009

19

PAI-1 Regulates the Invasive Phenotype in Human Cutaneous Squamous Cell Carcinoma

Freytag, Jennifer, Wilkins-Port, Cynthia E., Higgins, Craig E., Carlson, J. Andrew, Noel, Agnes, Foidart, Jean-Michel, Higgins, Stephen P., Samarakoon, Rohan, Higgins, Paul J.

Journal:

Journal of Oncology

Year:

2009

Language:

english

File:

PDF, 4.37 MB

english, 2009

20

TGF-β1–p53 cooperativity regulates a profibrotic genomic program in the kidney: molecular mechanisms and clinical implications

Higgins, Craig E., Tang, Jiaqi, Mian, Badar M., Higgins, Stephen P., Gifford, Cody C., Conti, David J., Meldrum, Kirstan K., Samarakoon, Rohan, Higgins, Paul J.

Journal:

The FASEB Journal

Year:

2019

Language:

english

File:

PDF, 2.26 MB

english, 2019

21

Rac-GTPase promotes fibrotic TGF-β1 signaling and chronic kidney disease via EGFR, p53, and Hippo/YAP/TAZ pathways

Patel, Samik, Tang, Jiaqi, Overstreet, Jessica M., Anorga, Sandybell, Lian, Fei, Arnouk, Alex, Goldschmeding, Roel, Higgins, Paul J., Samarakoon, Rohan

Journal:

The FASEB Journal

Year:

2019

Language:

english

File:

PDF, 2.60 MB

english, 2019

22

Anatomical relations of the superficial sensory branches of the radial nerve: a cadaveric study with clinical implications

Lasitha B Samarakoon, Kasun C Lakmal, Sharmila Thillainathan, Vipula R Bataduwaarachchi, Dimonge J Anthony, Rohan W Jayasekara

Journal:

Patient Safety in Surgery

Year:

2011

Language:

english

File:

PDF, 386 KB

english, 2011

23

PAI-1: An Integrator of Cell Signaling and Migration

Czekay, Ralf-Peter, Wilkins-Port, Cynthia E., Higgins, Stephen P., Freytag, Jennifer, Overstreet, Jessica M., Klein, R. Matthew, Higgins, Craig E., Samarakoon, Rohan, Higgins, Paul J.

Journal:

International Journal of Cell Biology

Year:

2011

Language:

english

File:

PDF, 642 KB

english, 2011

24

Rac-GTPase promotes fibrotic TGF-β1 signaling and chronic kidney disease via EGFR, p53, and Hippo/YAP/TAZ pathways

Patel, Samik, Tang, Jiaqi, Overstreet, Jessica M., Anorga, Sandybell, Lian, Fei, Arnouk, Alex, Goldschmeding, Roel, Higgins, Paul J., Samarakoon, Rohan

Journal:

The FASEB Journal

Year:

2019

File:

PDF, 2.60 MB

2019

25

Integration of non-SMAD and SMAD signaling in TGF-β1-induced plasminogen activator inhibitor type-1 gene expression in vascular smooth muscle cells

Samarakoon, Rohan, Higgins, Paul J.

Journal:

Thrombosis and Haemostasis

Year:

2008

File:

PDF, 510 KB

2008

26

Prevalence of chromosomal abnormalities in Sri Lankan women with primary amenorrhea

Samarakoon, Lasitha, Sirisena, Nirmala D., Wettasinghe, Kalum T., Kariyawasam, Kariyawasam Warnakulathanthrige Jay, Jayasekara, Rohan W., Dissanayake, Vajira H. W.

Journal:

Journal of Obstetrics and Gynaecology Research

Year:

2013

Language:

english

File:

PDF, 380 KB

english, 2013

27

Induction of renal fibrotic genes by TGF-β1 requires EGFR activation, p53 and reactive oxygen species

Samarakoon, Rohan, Dobberfuhl, Amy D., Cooley, Catherine, Overstreet, Jessica M., Patel, Samik, Goldschmeding, Roel, Meldrum, Kirstan K., Higgins, Paul J.

Journal:

Cellular Signalling

Year:

2013

Language:

english

File:

PDF, 4.04 MB

english, 2013

28

MP24-13 EVALUATION OF PROTEIN PHOSPHATASE PPM1A AS A NOVEL TARGET IN RENAL FIBROSIS

Rehfuss, Alexandra, Higgins, Paul, Samarakoon, Rohan

Journal:

The Journal of Urology

Year:

2016

Language:

english

File:

PDF, 146 KB

english, 2016

29

Protein phosphatase Mg 2+ /Mn 2+ dependent‐1A and PTEN deregulation in renal fibrosis: Novel mechanisms and co‐dependency of expression

Tang, Jiaqi, Goldschmeding, Roel, Samarakoon, Rohan, Higgins, Paul J.

Journal:

The FASEB Journal

Year:

2019

File:

PDF, 1.77 MB

2019

30

SERPINE1 (PAI-1) is deposited into keratinocyte migration “trails” and required for optimal monolayer wound repair

Kirwin M. Providence, Stephen P. Higgins, Andrew Mullen, Ashley Battista, Rohan Samarakoon, Craig E. Higgins, Cynthia E. Wilkins-Port, Paul J. Higgins

Journal:

Archives of Dermatological Research

Year:

2008

Language:

english

File:

PDF, 446 KB

english, 2008

31

SERPINE1 (PAI-1) Is a Prominent Member of the Early G0 → G1 Transition “Wound Repair” Transcriptome in p53 Mutant Human Keratinocytes

Qi, Li, Higgins, Stephen P, Lu, Qi, Samarakoon, Rohan, Wilkins-Port, Cynthia E, Ye, Qunhui, Higgins, Craig E, Staiano-Coico, Lisa, Higgins, Paul J

Journal:

The Journal of Investigative Dermatology

Year:

2007

Language:

english

File:

PDF, 567 KB

english, 2007

32

Linking cell structure to gene regulation: Signaling events and expression controls on the model genes PAI-1 and CTGF

Rohan Samarakoon, Margarete Goppelt-Struebe, Paul J. Higgins

Journal:

Cellular Signalling

Year:

2010

Language:

english

File:

PDF, 739 KB

english, 2010

33

TGF-β signaling in tissue fibrosis: Redox controls, target genes and therapeutic opportunities

Rohan Samarakoon, Jessica M. Overstreet, Paul J. Higgins

Journal:

Cellular Signalling

Year:

2013

Language:

english

File:

PDF, 640 KB

english, 2013

34

TGF-β1/p53 signaling in renal fibrogenesis

Higgins, Stephen P., Tang, Yi, Higgins, Craig E., Mian, Badar, Zhang, Wenzheng, Czekay, Ralf-Peter, Samarakoon, Rohan, Conti, David J., Higgins, Paul J.

Journal:

Cellular Signalling

Year:

2018

Language:

english

File:

PDF, 852 KB

english, 2018

35

TGF-β1-induced plasminogen activator inhibitor-1 expression in vascular smooth muscle cells requires pp60c-src/EGFRY845 and Rho/ROCK signaling

Rohan Samarakoon, Stephen P. Higgins, Craig E. Higgins, Paul J. Higgins

Journal:

Journal of Molecular and Cellular Cardiology

Year:

2008

Language:

english

File:

PDF, 1.65 MB

english, 2008

36

Anatomical landmarks for safer carpal tunnel decompression: an experimental cadaveric study

Samarakoon, Lasitha B, Guruge, Malith H, Jayasekara, Madusha, Malalasekera, Ajith P, Anthony, Dimonge J, Jayasekara, Rohan W

Journal:

Patient Safety in Surgery

Year:

2014

Language:

english

File:

PDF, 1019 KB

english, 2014

37

PD12-09 CONNECTIVE TISSUE GROWTH FACTOR INDUCTION PROMOTES EPITHELIAL MALADAPTIVE REPAIR IN RENAL FIBROSIS

Arnouk, Alex, Goldschmeding, Roel, Higgins, Paul, Samarakoon, Rohan

Journal:

The Journal of Urology

Year:

2017

Language:

english

File:

PDF, 106 KB

english, 2017

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